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Choose Prescription Weight Loss Tirzepatide vs Semaglutide on MACE
In head-to-head studies tirzepatide consistently shows a larger reduction in major adverse cardiovascular events than semaglutide, making it the preferred option for patients at high cardiac risk. In 2024 tirzepatide lowered MACE by 24% compared with placebo, outpacing semaglutide's 16% reduction (Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in