semaglutide
9 Proven Strategies to Preserve Muscle on GLP‑1 Weight Loss: semaglutide vs tirzepatide
In a head-to-head analysis, tirzepatide preserved 15% more lean mass than semaglutide over a 68-week period, offering a clearer path for athletes who want to shed fat without sacrificing strength. Both drugs activate GLP-1 pathways, yet their downstream effects on muscle protein balance differ enough to merit a tailored approach.